Endocrine Abstracts

Aims: We aimed to evaluate the relationship between glycosylated hemoglobin (HbA1c), time-in-range (TIR), Glucose Management Index (GMI) and coefficient of variation (CV) in a cohort of adult patients with type 1 diabetes (T1DM) and flash glucose monitoring (FGM).Material and methods: Cross-sectional study of patients with T1DM who FGM from Córdoba, Spain. Demographic and analytical data were collected. Glucose metrics and engagement statistics (adj...

Introduction: Ovarian cancer is the most lethal gynecological malignancy. Early diagnosis has a survival rate of 90%. Unfortunately, more than 70% of cases are diagnosed when the cancer has already metastasized, and survival rates do not exceed 30% in these cases. The sodium iodide symporter (NIS) is an integral plasma membrane glycoprotein expressed in the basolateral surface of the thyroid gland, where it mediates active transport of iodide. Radioiodide therapy (RAI) through...

Introduction: Obesity is a global health challenge with more than 60% of the world´s population with obesity living in LMICs. Studies have demonstrated that women are more affected by obesity than men. However, the risk of obesity and obesity-related cardiometabolic diseases in women in LMICs have not been documented. The aims of this meta-analysis are: to evaluate the risk of obesity and obesity-related cardiometabolic disease in women compared to men in LMICs and to eva...

Introduction: Obesity is a pathological condition characterized by a low-grade systemic inflammatory state that predisposes to the onset of some diseases, such as hypertension, diabetes, and hyperlipidemia. Also, obesity can impact bone metabolism, but its effects are controversial.Aims: This observational study aimed to evaluate and correlate the bone mass with the lipidic profile, adipocytokines, glucose metabolism, hepatic function and purine metaboli...

Background: Medical treatment for acromegaly (characterized by excess growth hormone [GH] production) includes somatostatin receptor ligands (SRLs), dopamine agonists (DAs), and GH receptor antagonists (GHRAs). However, recent real-world United States (US) treatment evaluations are few. We present treatment patterns for patients receiving medications for acromegaly (1/1/2010–31/7/2022).Methods: De-identified data were extracted from MarketScan&...

Objective: Owing to their remarkable stability in the serum, microRNAs are being investigated as circulating cancer biomarkers. Several studies have explored their plasma or serum levels in thyroid cancer in order to differentiate benign from malignant nodules preoperatively. However, very few studies have explored the role of microRNAs to detect recurrent disease during postoperative follow-up and none of them used high through-put technologies. Recombinant human TSH (rhTSH) ...

Objective: To study the relation between incretin-based therapies, DPP-4 inhibitors and GLP-1 receptor agonists, and tumor stage at the time of diagnosis of pancreatic and biliary tract cancer.Methods: Retrospective study of type 2 diabetic patients with newly diagnosed of pancreatic or biliary tract cancer attended consecutively in a tertiary hospital between the years 2012 and 2015.Results: A total of 37 patients were included. T...

Introduction: 39% of morbidly obese patients have type 2 diabetes mellitus (T2DM) and 80% of them can achieve diabetes remission after bariatric surgery. However, there are few randomized studies comparing the metabolic results of different surgical techniques and the hormonal mechanisms involved.Objective: To study and compare the improvement of T2DM and the hormonal pathways following three surgical techniques: metabolic gastric bypass (mGBP), sleeve g...

Thyroid hormone resistance (THR) is a rare dominantly inherited syndrome characterized by a reduced response of target tissues to thyroid hormone receptor. In most cases, THR is related to mutations in the thyroid hormone receptor beta gene (THRb). Management may be challenging in cases of gestation. Here we report the case of a pregnant patient with a possible not previously described mutation and negative genotype fetus.Case report: Thirty-two year old...

Objective: To evaluate the characteristics and glycemic control in admitted patients with type 2 diabetes and high vascular risk. To analyze therapeutic switch effect at hospital discharge on medium term metabolic control.Methods: Cross-sectional study including patients with type 2 diabetes and high vascular risk. Demographic and clinical characteristics, laboratory parameters, and diabetes treatment at baseline and discharge were analized. We used a sp...